Ungrar, the King of Viruses, has escaped from his prison cell in Vaccine World. Maya, the Goddess of Vaccine World sends Mugimaru down to Earth to find a human to accept the powers of Vaccine World and become the Magical Nurse. He finds the best (and the only willing) person for the job when he meets Komugi Nakahara. Komugi is a playful, lazy, and easily distracted (typical) teenager whose dream is to become a cosplay idol. Balancing her career with the Kiri-Pro Promotion Company and her new job battling Ungrar's loyal henchman, the Magical Maid Koyori, Komugi delights audiences in this parody anime series.

After the three-pronged conflict between tyrannical electric company Shinra, rebel group Avalanche, and the maniacal Sephiroth, the damaged planet slowly heals its wounds. A rural town dubbed Edge sprouts up on the outskirts of Midgar's ruins. Reeve Tuesti, former Head of Urban Development at Shinra, interviews a young boy named Denzel for potential membership in Reeve's World Regenesis Organization, a group devoted to the restoration and protection of the planet. Denzel recounts his tragic history to Reeve, detailing how the aftermath of the heroic Avalanche's actions laid waste to Midgar and took the lives of everyone the boy knew. Through reminiscing to Reeve, Denzel discovers a newfound purpose.

A TV special, known as episode 2.5, that takes place between episodes 2 and 3.