Amsterdam, June 12, 1942. Anne celebrates her 13th birthday and begins her diary, which she calls "Kitty". Hiding for two years from the German threat, the young girl writes about her idealistic views on the world, her ambitions, her fears and her first love, Peter.

An untidy room. Empty beer tins, empty wine bottles, a half-empty glass of whisky... A girl is getting up absent-mindedly and starts preparing herself. YOUR morning starts. Lazy and hard-to-wake-up YOU. The emoticon is ME watching over YOU. I play tricks on YOU, while YOU are playing the guitar and drinking. One day, in town, YOU walk past THE CHILDHOOD FRIEND who is buying an Anemone I liked, and remembering that I liked them, YOU rush out to buy them. THE CHILDHOOD FRIEND displays the Anemone with care. One day, years after I died, YOU hear noise from the closet. Opened, YOU see MY garden right in front of YOU. Overflowing emotions of ME and YOU. When exiting from the room with memories, a picture of the Anemone that YOU painted is displayed in YOUR new room.

Black Jack is an "unregistered" doctor with a clouded, mysterious past. He works with his little assistant Pinoko (who has a massive crush on the doctor), dealing with medical cases not very well known, which can be strange, dangerous, or not known at all. But he is a genius, and can save almost any of his patients' life (as long as they have the money for it, that is), and is known to many around the world, especially to those of medicine and science. He's a man of science himself, and does not believe much until he has seen it, yet it is many times he is surprised by love and nature often overpowering the science he bases his life in.

Cosplay City is in danger when the evil Dolmeck shows up. Commanding his army of monsters, he plans on destroying everything. Only one person can stop this: Cutey Honey. After she is released from her dormancy, Honey Kisaragi becomes the multi-transformational android Cutey Honey. However, the least is expected when Honey is faced with an old enemy from the past: Panther Zora.