Meet Tamako, who's found her way into an interview at a ramen shop run solely by cats. When the feline manager asks if she likes cats, Tamako admits that she's actually more of a dog person...only to be hired on the spot! But her job description isn't quite what she expects — rather than serving ramen, she's now a dedicated cat caretaker...?!

Three hundred years ago, a genetic experiment gone wrong caused the mutation of all forests on Earth. Armed with consciousness, the vegetation sought to destroy all of humankind, and the war that ensued turned the planet into a hellish dystopia. In the present day, Agito, a young boy, lives with his father in Neutral City—a village maintaining an uneasy truce with the neighboring forest. One day, Agito, on his way to collect water, becomes separated from his friend and stumbles upon a relic of the past: a girl sleeping in a mysterious machine. Agito awakens the girl, Toola Cm Sacl, and introduces her to the village. But outside forces have ulterior motives for the girl, who holds the key to restore the Earth. Misguided by Shunack, a soldier from the old world hellbent on destroying the forest, Toola follows him despite Agito's warning. Determined to save Toola and unify humankind with the forest, Agito borrows the power of the forest and pursues her.

The story is set in the year 311 of the Orbital Calendar, when humanity has migrated to countless colony clusters in space. A space colony girl named Akiha Shishidou encounters a malevolent artificial intelligence named Leopard that has been installed on a colony. Akiha is joined by an Inter-Colony Police officer named Itsuki Kannagi, a taciturn young girl named Honoka Kawai, and a robot named Imoko "Imo-chan" Shishidou.

The dream of the young man "Qian Cong" is to be able to study at school and to become "the strongest commander of hunting guards ". This is a long and challenging road.