Vampires—supernatural beings that feed on the life essence of the unsuspecting at night—have been around for centuries. However, high schooler Karin Maaka is unusual, even among her own kind. Unlike her vampire family, ever since she was a child, Karin has suffered from polycythemia: a rare disorder which causes her to periodically produce excessive amounts of blood. And the more blood she produces, the more anemic and lightheaded she gets, ultimately leading to frequent nosebleeds. Her only solution? Force her excess blood onto random strangers, which surprisingly causes these "victims" to become livelier and happier than before. With her siblings—Anju, her reserved yet affectionate younger sister, and Ren, her womanizing elder brother—helping her abilities remain a secret by altering the affected humans' memories, no one is the wiser. That is, until Karin's newly transferred classmate, Kenta Usui, finds her behavior suspicious. And to make matters even more complicated, Karin feels her blood reacting unusually to Kenta's presence.

Katsu Kaizou is a very gullible, 17-year-old high school student and a believer in science fiction, aliens, ghosts, UFOs, conspiracies, etc. He thinks that everything going on around him is the result of some sort of alien plot to take over the world. Each story is pretty much self-contained and is completely bizarre. Kaizou joins the school's science club, makes new friends, and ends up coming in contact with all sorts of strange things like log people, deadly sushi, pee-blades, scary infections, robot invasions, ghosts, living dolls, and more!

In search for Araki Genzo, George Kodama finds himself in the small town of Kimujuku. George quickly realizes that he is unwelcome and is warned to leave as soon as possible. With two rival syndicates roaming the streets and a dark violent past, the town of Kimujuku isn't what it appears to be. George challenges the town of Kimujuku in order to reveal the towns dark hidden past and discover the truth.

With Tomura Shigaraki at its helm, the former Liberation Army is now known as the Paranormal Liberation Front. This organized criminal group poses an immense threat to the Hero Association, not only because of its sheer size and strength, but also the overpowering quirks of Jin "Twice" Bubaigawara and Gigantomachia. As new intel from the covert hero Keigo "Hawks" Takami confirms that Shigaraki is nowhere to be seen, the Hero Association decides to strike the enemy headquarters with a surprise attack using the entirety of its assets—and the UA students find themselves on the battlefield once again. As the fight rages on, the unsuspecting villains must regroup and push back, but the brave heroes are determined to eradicate every last one of them.