As with its prequel, Zoku Natsume Yuujinchou is about Takashi Natsume, a boy who has had the ability to see youkai since he was young, and his bodyguard youkai Madara, nicknamed Nyanko-sensei. Natsume attempts to return names written in his "Book of Friends" (which he inherited from his grandmother Reiko) to youkai in his village. Throughout these adventures, he meets some youkai that are friendly, some that want to steal the Book, and some that want to kill him, as Natsume learns about himself and his relationship with these mysterious beings along the way.

After a mysterious spaceship crashes into Earth, humanity realizes that they are not alone. Fearing a potential threat from space, the world pushes aside their nationalism, conflicting interests, and cultural differences, unifying under the banner of the United Nations. The newly formed UN forces decide to repurpose the alien spacecraft, naming it SDF-1 Macross. Unfortunately, on the day of its maiden voyage, a fleet of spaceships belonging to a race of aliens known as the Zentradi descend upon Earth, and the SDF-1 Macross, acting of its own accord, shoots down the incoming squadron, sparking an intergalactic war. In an attempt to escape, the Macross tries to launch itself into the Moon's orbit, but the ship—as well as the city it was in—is teleported to the far reaches of space. Caught up in this mess are Hikaru Ichijou, a free-spirited acrobatic pilot, and Minmay Lynn, an aspiring singer. These two, alongside Macross' crew, experience an epic journey rife with grief and drama, coming face-to-face with the cruelties of war along the way. [Written by MAL Rewrite]

While most fifteen-year-old boys, in one way or another, harbor secrets that are related to girls, Takashi Natsume has a peculiar and terrifying secret involving youkai: for as long as he can remember, he has been constantly chased by these spirits. Natsume soon discovers that his deceased grandmother Reiko had passed on to him the Yuujinchou, or "Book of Friends," which contains the names of the spirits whom she brought under her control. Now in Natsume's possession, the book gives Reiko's grandson this power as well, which is why these enraged beings now haunt him in hopes of somehow attaining their freedom. Without parents and a loving home, and constantly being hunted by hostile, merciless youkai, Natsume is looking for solace—a place where he belongs. However, his only companion is a self-proclaimed bodyguard named Madara. Fondly referred to as Nyanko-sensei, Madara is a mysterious, pint-sized feline spirit who has his own reasons for sticking with the boy. Based on the critically acclaimed manga by Yuki Midorikawa, Natsume Yuujinchou is an unconventional and supernatural slice-of-life series that follows Natsume as he, with his infamous protector Madara, endeavors to free the spirits bound by his grandmother's contract.

The everyday Sanyo family gets an unexpected surprise in the shape of a new lodger-Hattori is a ninja boy who has come down from the Iga mountains to attend normal school. Befriending Kenichi Sanyo, who is the same age as he, Hattori starts attending school undercover, occasionally accompanied by his brother, Shinzo, Shishimaru the ninja dog, and Kenichi's girlfriend, Yumeko. The gang is also threatened by the rival Koga ninja, Kemumaki, and his evil sidekick, Kagechiyo the Shadow-cat. (Source: The Anime Encyclopedia)