In a shocking turn of events, humanity has won its first battle in the Ragnarök tournament—a series of 13 fights that will decide the fate of mankind. Zeus, the head of gods, sends the demigod Heracles for the next round to avenge the humiliated Greek pantheon. To face this hero loved by gods and humans alike, the Valkyrie Brunhilde decides to use Heracles' complete moral opposite: the infamous serial killer Jack the Ripper—leaving human beings unsure who they should support. Meanwhile, tensions begin to rise between various divine pantheons, and rumors of a traitor jeopardize the unity of those who want to annihilate humanity. As the line between friend and foe becomes blurred, Brunhilde will do everything she can to make her machinations successful.

Years after an ancient evil was salvaged from the depths of the sea, Joutarou Kuujou sits peacefully within a Japanese jail cell. He's committed no crime yet demands he not be released, believing he's been possessed by an evil spirit capable of harming those around him. Concerned for her son, Holly Kuujou asks her father, Joseph Joestar, to convince Joutarou to leave the prison. Joseph informs his grandson that the "evil spirit" is in fact something called a "Stand," the physical manifestation of one's fighting spirit which can adopt a variety of deadly forms. After a fiery brawl with Joseph's friend Mohammed Avdol, Joutarou is forced out of his cell and begins learning how to control the power of his Stand. However, when a Stand awakens within Holly and threatens to consume her in 50 days, Joutarou, his grandfather, and their allies must seek out and destroy the immortal vampire responsible for her condition. They must travel halfway across the world to Cairo, Egypt and along the way, do battle with ferocious Stand users set on thwarting them. If Joutarou and his allies fail in their mission, humanity is destined for a grim fate.

With a cartload of fur pelts in tow, traveling merchant Kraft Lawrence stops by the village of Pasloe. According to local folklore, centuries ago, one of the villagers made a promise with the wolf deity Holo, who swore to bless Pasloe with bountiful harvests of wheat. Yet, as time passed, such stories became little more than relics of the past. After quickly finishing his business in the village, Lawrence sets out to his next destination. His journey, however, takes an unexpected turn when he discovers a nude, animal-eared girl sleeping among his pelts. Even more surprisingly, the youthful-looking woman claims to be Holo—the wolf of legend. Holo wishes to return to her hometown in the north, and though their first encounter is rocky, she convinces Lawrence to accompany her on her travels. In return, she vows to earn her keep, using her quick wits and lifetime of experience to help her newfound companion in his dealings. As they continue their journey, Lawrence and Holo take advantage of whatever economic opportunities they come across, often landing in situations that put both their business skills and their relationship to the test.

After an enthusiastic invitation from her friend, Kaede Honjou reluctantly agrees to try New World Online: a very popular VRMMO played by thousands of people across Japan. Naming her in-game character Maple, she sets out on her journey. As a complete novice to such games, she allocates all of her stat points into vitality, desiring to not get hurt. With not a single point in any other stat, Maple has extraordinarily high defense, but she can't move quickly or hit hard. This doesn't end badly for her, however. Due to her high defense, Maple acquires overpowered skills such as Total Defense, Poison Immunity, and Devour. These skills, along with the incredibly powerful items she obtains, allow her to obliterate most enemies in a single hit. After only a few days of playing the game, Maple claims third place in a server-wide event, gaining a reputation as a player who is both unkillable and absurdly powerful. Despite her overpowered character, Kaede has much to learn. As she progresses through the game, she meets new friends and acquaintances, helping her complete new levels and events. Through all of her adventures, she may even pick up some other crazy skills that exceed all expectations. [Written by MAL Rewrite]