In a civilized society of anthropomorphic animals, an uneasy tension exists between carnivores and herbivores. At Cherryton Academy, this mutual distrust peaks after a predation incident results in the death of Tem, an alpaca in the school's drama club. Tem's friend Legoshi, a grey wolf in the stage crew, has been an object of fear and suspicion for his whole life. In the immediate aftermath of the tragedy, he continues to lay low and hide his menacing traits, much to the disapproval of Louis, a red deer and the domineering star actor of the drama club. When Louis sneaks into the auditorium to train Tem's replacement for an upcoming play, he assigns Legoshi to lookout duty. That very night, Legoshi has a fateful encounter with Haru, a white dwarf rabbit scorned by her peers. His growing feelings for Haru, complicated by his predatory instincts, force him to confront his own true nature, the circumstances surrounding the death of his friend, and the undercurrent of violence plaguing the world around him. [Written by MAL Rewrite]

After years of animosity, the leaders of Osaka's Somei and Tokyo's Miyama yakuza groups have called a truce—by arranging an engagement between their respective grandchildren, Yoshino Somei and Kirishima Miyama. To this end, 17-year-old Yoshino moves to Tokyo to live with the Miyama family and attend school with her new fiancé. Although Kirishima is all smiles and perfectly polite, there is something unsettling about his demeanor that Yoshino cannot put her finger on. Yoshino's suspicions are soon confirmed: despite his manners, Kirishima is a masochistic maniac. He hurts people without batting an eye and also revels in being punished verbally and physically himself. What he wants most is a spoiled and arrogant fiancée who will ruin his life. When Yoshino does not quite meet his expectations, he reveals his true colors and openly insults her. However, instead of running away in fear, Yoshino decides to take revenge by making Kirishima fall in love with her and then ruthlessly breaking his heart.

Although cheerful and delicate, Sakura Sakurakouji is a skilled martial artist with a sense of fairness that never falters—no matter the situation. Upon witnessing people burning in blue flames while on a bus ride home, she calls the police to bring their murderer to justice only to find that no evidence remains. However, all her doubts about what she saw vanish when the next day, the new transfer student Rei Oogami joins her class; he is the very boy she watched commit murder in cold blood. Rei is kind, sweet, and quickly becomes popular, contradicting Sakura's accusations. Soon enough, she learns his true nature: a Code Breaker, or "one who does not exist." To Sakura's shock, Rei—armed with mysterious powers—seeks to exact justice according to the principle of "an eye for an eye." Determined to bring Rei to the right path, Sakura keeps close to him in the hopes of redeeming him from his ways before others are hurt. [Written by MAL Rewrite]

Despite having seemingly quelled the war between their respective gangs, Raku Ichijou and Chitoge Kirisaki still carry on with their fake relationship. Eventually, as Chitoge's perception of Raku slowly changes, she even begins to see him as a little charming. Chitoge struggles to come to terms with her newfound feelings for Raku, as a new girl joins the slew of Raku's admirers and the competition among those vying for the yakuza heir's attention grows even fiercer. And amidst all this, Raku's search for his first love and the contents of the mysterious sealed locket continues in Nisekoi:, which picks up where the first season left off. [Written by MAL Rewrite]