High school girl duo Popuko and Pipimi are back and more unhinged than ever after their initial efforts to create a full-fledged anime production were met with a great reception. With no regard for their audience, they continue to live their reckless everyday lives consisting of comedy skits and parodies of epic proportions. No one is immune to the effects of their antics—including hapless live actor Shouta Aoi, who is on the run and stuck trying to be a hero in the wrong series.

In the future, the moon is a habitable place with atmosphere and gravity and also a famous tourist attraction. There are also stories about a "long ears" creature like rabbits on the moon who can use magic. Haruka Daichi heads off to the moon during a summer holiday alone because he likes to see the long ears creature by himself. However, he get himself dragged into an ancient conflict between two ancient moon races: the "long ears" race and Jado race. Jado race wanted to conquer the universe and resurrect ancient evil powers to seize control of the Earth. Now the "long ears" race and Daichi must seek three warriors who could use magic to release Mado King to fight Jado race and to release "long ears" race's kingdom, Rabiluna, from Jado race.

College student Yuuhi Amamiya's monotonous life is turned upside down with the appearance of Sir Noi Crezant, a talking lizard claiming to be a knight of justice. Crezant elaborates that the world is in peril—threatened by the mage Animus who wishes to annihilate it with his Biscuit Hammer, an enormous structure suspended in Earth's orbit. As the newly appointed Lizard Knight, Yuuhi must fight alongside other Beast Knights to protect the princess and save the planet from destruction. Unimpressed by the prospect of risking his life, Yuuhi continues his day as usual—until a golem created by Animus suddenly confronts him. Yuuhi is instantly overpowered, but his neighbor, Princess Samidare Asahina, luckily rescues him. To his surprise, Samidare's intention starkly differs from Crezant's; instead of saving the world, she aims to destroy it with her own hands. Captivated by her firm ambition, Yuuhi resolves to become stronger and help Samidare realize her goal. As the pair continues to fight against Animus' golems, Yuuhi finds himself gradually gaining an interest in life—but the chains of his past trauma may restrain him from progressing further.