A 30-year-old man who dreams of becoming a wizard suddenly loses his life. Reincarnated in another world as a young child named Shion, he grows up alongside Marie, his dependable older sister who adores him. Shion eagerly anticipates using magical powers, but he discovers that the new world seemingly does not have any magic. He spends the ensuing years as a gloomy and dejected child until a mystical phenomenon at a nearby lake catches the siblings' attention and breathes life back into his magical dream. While experimenting on the peculiar light emanating from the water, Shion finally confirms that magical energy really exists. It may not be convenient for anything just yet, but Shion devotes his time to studying the anomaly, determined to uncover all the existing wonders in his quest to make magic.

Shun Asanaga is a 15-year-old junior high school student with an optimistic and bright personality. One day, he finds a mysterious crystal in the office of his father, who is a scientist and businessman. When Shun touches it, the world becomes distorted, and he is sent into the world of Endra. Emilio, a prince of the kingdom of Endra, is nearing his 16th birthday and despises the reigning king, Delzain. Since Emilio is now at the age when he can inherit the throne, he takes up a weapon and attempts revenge. However, because Emilio is too weak, he is captured by Delzain and put in prison. When Emilio is in grief, the wall of his cell becomes distorted and Shun appears from there with two goals: return to his own world, and complete Emilio's revenge. What future lies ahead for the two boys trying to survive in Endra, yet raised in two different worlds?

Since their days as students, Tsukasa Jinguuji has had incredible luck with women due to his good looks; Hinata Tachibana has had almost none, overshadowed by Jinguuji's brilliance. However, while Jinguuji has never shown interest in the opposite sex, Tachibana is always desperate for a girlfriend. Despite their polar differences, they continue to be best friends even in their thirties as salarymen. One night, the two are returning home from a mixer where Jinguuji was the center of attention as usual. In his drunken rambles, a frustrated Tachibana inadvertently wishes to become a beautiful girl with irresistible charm. As if the heavens were listening, a goddess suddenly shows herself before Jinguuji and Tachibana, transporting them to another world to defeat the Demon Lord and simultaneously granting Tachibana's desire. Tachibana—now in the body of an impossibly perfect woman—has become so attractive that even Jinguuji is captivated. Moreover, Tachibana grows aware of Jinguuji's stunning appearance, finally understanding his popularity. Before they fall in love with each other, the duo must complete their mission or risk remaining prisoners to their infatuations forever.

A strange environmental phenomenon 22 years ago in the Kanazawa prefecture caused the land to split and protrude upwards reaching unprecedented heights, creating the secluded area known as The Lost Ground. Kazuma is a young mercenary who lives in the Lost Ground, looking for any work he can find to sustain his livelihood within the harsh environment. He is one of the few people that are gifted with the Alter ability, which allows him to plaster his right arm and torso with a metallic alloy. When this mercenary encounters HOLY, an order whose purpose is to suppress and capture what they call Native Alter Users, and one of the elite members of HOLY, Ryuho, an epic rivalry begins.