Iria is the story of a girl and the Alien being she loves to hate. The series begins with her brother, Gren, taking a job. He is a bounty hunter, and one well known for his incredible skill. Iria, being a skilled apprentice bounty hunter herself, tags along. What is the job, one might ask. It is to find out what has happened to the crew and cargo of a Space Station. Needless to say, nothing is as it seems, and the war between Iria and Zeiram begins in earnest.

Despite the Ends’ attack on Verlina being successfully repelled, the war has not yet ended. With the monster armies regrouping, the Black King tightens his grasp on the already conquered territory. New conflicts erupt all across Orte, as its remaining forces struggle to retain control over long-oppressed demi-human races. While Ends grow more potent each day, Toyohisa Shimazu remains unconscious after heavy injuries suffered during the Battle of Verlina. Facing enemies on every side, humanity’s fate is still on a knife's edge.

With reports of monsters terrorizing the reactor at Mount Nibel, the Shinra Electric Power Company dispatches their elite fighting force SOLDIER to investigate. Accompanied by fellow SOLDIER First Class Zack Fair and a small contingent of company guards, the war hero Sephiroth is to assess the condition of the Mako reactor at the behest of the company. In Nibelheim, the village that the reactor powers, Sephiroth discovers the source of the monsters and the origins of Shinra's legendary Jenova Project. Running through the woods months later, Zack is no longer the hero he once dreamt of becoming. He flees from the General Affairs Department of the Shinra Electric Power Company, better known as the Turks, who desperately seek to bury the evidence living within the two.