​On the island of Regalo, a group of supernaturally powered mafia-like protectors called the Arcana Famiglia safeguard the people from any who would harm them. The members of their organization, having made contracts with tarot cards, each possess different abilities, such as overwhelming strength, invisibility, or the power to see into someone's heart. Mondo, their leader and the "Papa" of their family, announces at his birthday party that he will be retiring soon. He plans to hold the Arcana Duello, a competition that, if won, will grant the winner the title of Papa and any wish they desire. But there is more at stake than just a title: Mondo also decides that the winner will marry his daughter, Felicità. Enraged by this, the strong-willed Felicità decides to enter the competition herself, in order to make her own way in the world. As Felicità battles for her freedom, her competitors battle for her heart.

The story follows Elk, a bounty hunter in some strange futuristic world. On this world archaic but advanced technology exists side by side with primitive attitudes, beasts and magic. In other words it's got a bit of everything. It also has an evil conspiracy who are able to produce powerful monsters called chimera, who can also appear as human. Naturally it is not long before Elk has rescued a young female beast-master and gained himself some serious enemies.

The anime will follow the adventures of Baron, a man living on continent of Arad in the year 981 after "the cursed light of Kazan" has fallen across the land. Thanks to the curse, one of his arms has become possessed. After finding a sword that has been possessed by the spirit Roxy, he embarks on a quest to unravel the secret of the curse and meets various people who also join his party.

Supersonic monkeys, vampires, talking fishmen, and all sorts of different supernatural monsters living alongside humans—this has been part of daily life in Hellsalem's Lot, formerly known as New York City, for some time now. When a gateway between Earth and the Beyond opened three years ago, New Yorkers and creatures from the other dimension alike were trapped in an impenetrable bubble and were forced to live together. Libra is a secret organization composed of eccentrics and superhumans, tasked with keeping order in the city and making sure that chaos doesn't spread to the rest of the world. Pursuing photography as a hobby, Leonardo Watch is living a normal life with his parents and sister. But when he obtains the "All-seeing Eyes of the Gods" at the expense of his sister's eyesight, he goes to Hellsalem's Lot in order to help her by finding answers about the mysterious powers he received. He soon runs into Libra, and when Leo unexpectedly joins their ranks, he gets more than what he bargained for. Kekkai Sensen follows Leo's misadventures in the strangest place on Earth with his equally strange comrades—as the ordinary boy unwittingly sees his life take a turn for the extraordinary.